Expert Roundtable: Scale-up considerations for improved yield in upstream viral vector production

Published: 17 February 2020
Expert Roundtable Video
Sven Ansorge,
Sven Ansorge
Director, Manufacturing at ExCellThera Inc.
Sven Ansorge Director of Manufacturing at ExCellThera Inc. Sven holds a PhD in Chemical Engineering and has led teams and managed projects within academic and industrial/GMP manufacturing environments. He is specialized in bioprocessing for the production of viral vectors, vaccines and recombinant proteins.
Mike Burnham,
Mike Burnham
Director, Vector Development at Tmunity Therapeutics Inc
Michael Burnham is the Director of the Vector Development department at Tmunity Therapeutics Inc. in Philadelphia. Mike has over 25 years’ of biosafety and bioprocessing expertise, and is currently working to establish Tmunity’s lentiviral vector manufacturing platform. Prior to joining the team, Mike worked at WuXi AppTec, serving in multiple roles in their Process Development, Viral Production/Purification and Viral Clearance departments. In these roles, Mike and his teams worked to develop new methods for virus purification and quantification, and to improve processes for the purification of client-specific biologics and gene therapy programs. Mike successfully developed novel purification strategies for multiple virus types to improve the growth, potency and quality of viruses used in Viral Clearance studies, as well as developing and validating assays for emerging viruses. He holds a BS in Biological Sciences from the University of Delaware and an MS in Biological Sciences from Rutgers University.
Michael Kelly,
Michael Kelly
Director, Asset Leadership, Gene Therapy at Biogen Idec
Dr. Mike Kelly has over 20 years of experience in the field of gene therapy. During this time, Mike has been responsible for various aspects of research, development and clinical manufacturing for a number of lentiviral, adenoviral and Adeno-associated virus (AAV) -based therapeutics. Currently, Mike works at Biogen, where he is a Director in the Asset Development and Portfolio Management group, leading the gene therapy portfolio. Prior to his current role, Mike was the Director of Gene Therapy Development at Genzyme Corporation, where he was responsible for process development and manufacturing for Genzyme’s gene therapy programs. Prior to that, Mike was most recently the Site Director at Genzyme’s development and clinical manufacturing facility in San Diego. Before joining Genzyme, Mike worked at Cell Genesys and Somatix Therapy Corporation, where he held various roles in research and development and clinical manufacturing for gene therapy programs.
Ruth McDermott,
Ruth McDermott
Platform Manager, Regenerative Medicine Applications at Sartorius
Ruth has 20 years of business and market development experience within the life sciences industry, including roles in technology and IP commercialization. Ruth’s technical knowledge has been built on a background of R&D in cell bioprocessing, stem cells and gene therapy. Ruth holds a PhD in Cell Biology and an MBA.
Peter Jones
Peter Jones
Manager
Head of Operational Strategy at Oxford Biomedica Peter has over 30 years’ experience in the biopharmaceutical industry. He joined Oxford Biomedica in 2011, providing technical and scientific leadership. In his current role, he is responsible for overseeing strategic and operational planning to develop the Company’s capabilities and capacity to support future business growth. Peter is a Fellow of the Institution of Chemical Engineers and the Royal Academy of Engineering Visiting Professor in Manufacturing of Advanced Therapies at Aston University.


Sven Ansorge

Director of Manufacturing at ExCellThera Inc.

Sven holds a PhD in Chemical Engineering and has led teams and managed projects within academic and industrial/GMP manufacturing environments. He is specialized in bioprocessing for the production of viral vectors, vaccines and recombinant proteins.

Mike Burnham

Director of the Vector Development department at Tmunity Therapeutics Inc.

Mike has over 25 years’ of biosafety and bioprocessing expertise, and is currently working to establish Tmunity’s lentiviral vector manufacturing platform. Prior to joining the team, Mike worked at WuXi AppTec, serving in multiple roles in their Process Development, Viral Production/Purification and Viral Clearance departments.

Michael Kelly

Vice President of Process Development at Avrobio

Avrobio is a clinical stage company developing gene therapies for rare diseases. Michael has over 20 years of experience in the field of gene therapy. During this time, Mike has been responsible for various aspects of research, development and clinical manufacturing for a number of lentiviral, adenoviral and AAV-based therapeutics.

Ruth McDermott

Segment Marketing Manager at Sartorius

Ruth has 20 years of business and market development experience within the life sciences industry, including roles in technology and IP commercialization. Ruth’s technical knowledge has been built on a background of R&D in cell bioprocessing, stem cells and gene therapy. Ruth holds a PhD in Cell Biology and an MBA.

Peter Jones

Head of Operational Strategy at Oxford Biomedica

Peter has over 30 years’ experience in the biopharmaceutical industry. He joined Oxford Biomedica in 2011, providing technical and scientific leadership. In his current role, he is responsible for overseeing strategic and operational planning to develop the Company’s capabilities and capacity to support future business growth. Peter is a Fellow of the Institution of Chemical Engineers and the Royal Academy of Engineering Visiting Professor in Manufacturing of Advanced Therapies at Aston University.